I suspect that the recipe I gave above for finding if the square contains any points of zero potential or field may contain some mathematical complications. As an alternative we might consider some symmetry arguments.
First with regard to the field, if all the charges had equal magnitude, then clearly the center of the square would be a point of zero field, where the contributions from the positive charges are equal and opposite and the contributions from the the negative charges are equal and opposite. Now if we allow the charge at a positive corner to increase, its contribution to the field will be larger than that from the opposite corner. Still somewhere on the line between those corners there will be a point where the field from those corner charges add to zero. When the other two corner charges are considered they will tend to shift the zero field point back toward the center of the square somewhat. Now if we let one of the negative charges increase in magnitude that will tend to move the point of zero field off the original diagonal but it will remain in the square as long as the increased charges are less than infinite.
Now considering the potential, if all the charges had equal magnitude, then the center of the square would be a point of zero potential, where the contributions from the negative charges and positive charges add to zero. Again, adjusting the amount of charge on two of the corners will just shift the location of this point around the square.
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